The Hemangioma Investigator Group (HIG) is a multi-institutional research consortium established in 1999. It consists of a network of investigators in the U.S., Canada, and Spain. A fundamental goal of HIG is to provide quality data on the safety and effectiveness of the novel application of therapeutics in infantile hemangiomas (IH). HIG has completed several longitudinal multi-site studies addressing the incidence, demographics, complication rate, and outcomes of IH. Since its inception, HIG has expanded to more than a dozen sites and has built a clinical research infrastructure, including data collection and management, formalized leadership and an administrative structure. HIG has collaboratively published over 40 studies, developed an educational website, and members have received a number of grants related to IH research. The HIG holds two meetings per year prior to the Academy of Dermatology Meeting and the Society for Pediatric Dermatology Meeting.